Homocysteine and Peripheral Neuropathy

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Association of Metformin, Elevated Homocysteine, and Methylmalonic Acid Levels and Clinically Worsened Diabetic Peripheral Neuropathy

OBJECTIVE The severity of peripheral neuropathy in diabetic patients varies for unclear reasons. Long-term use of metformin is associated with malabsorption of vitamin B(12) (cobalamin [Cbl]) and elevated homocysteine (Hcy) and methylmalonic acid (MMA) levels, which may have deleterious effects on peripheral nerves. The intent of this study was to clarify the relationship among metformin exposu...

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ژورنال

عنوان ژورنال: Journal of Neurology and Experimental Neuroscience

سال: 2020

ISSN: 2469-407X

DOI: 10.17756/jnen.2020-076